Change.

"Change, we don't like it, we fear it, but we can't stop it from coming. We either adapt to change or we get left behind. And it hurts to grow, anybody who tells you it doesn't is lying. But here's the truth: the more things change, the more they stay the same. And sometimes change is good. Oh, sometimes change is . . . everything."

(Meredith Grey)

"If there's just one piece of advice I can give you, it's this--when there's something you really want, fight for it, don't give up no matter how hopeless it seems. And when you've lost hope, ask yourself in 10 years from now, you're gonna wish you gave it just one more shot because the best things in life, they don't come free."
(Meredith Grey)